Efficacy Test

As per Taiwan FDA requests, health foods that claim functions as below should obtain approval of Health Food Registration before importing, manufacturing, or launching:

 

  • Blood lipid regulation
  • Blood glucose regulation
  • Immune modulation
  • Liver function protection
  • Gastrointestinal function improvement
  • Reduction of body fat accumulation
  • Bone health
  • Dental health
  • Anti-aging
  • Anti-fatigue
  • Assist in regulating blood pressure
  • Assist in modulating allergy constitution
  • Promotion of iron availability

 

Medgaea provides efficacy evaluation tests for Health Foods registration. According to the function design of the food product, we also deliver pilot studies for formula screening and dose range finding for our clients to reduce the cost and risk of new product development. Welcome to contact us.

Blood Lipid Regulation

  • Guideline

    Evaluation Method of Blood Lipid Regulation Effect of Health Food

  • Test system

    Male hamsters

  • Method

    1.  High fat diet-induced hyperlipidemia model (induction in advance)

    2  .High fat diet-induced hyperlipidemia model (induction and treatment at the same time)

  • Item

    Serum TG, TC, LDL-C, HDL-C, fecal lipids, liver lipids, etc.

Immune Modulation

  • Guideline

    Evaluation Method of Immuno-modulatory Effect of Health Food

  • Test system

    Male Balb/c mice

  • Method

    1.   Non-specific immune response

    2.   OVA-specific immune response

  • Item

    Immune cell proliferation ability, natural killer cell activity, phagocytic cell activity, cytokine analysis, serum antibody analysis, cell surface marker analysis of spleen lymphocyte, etc.

Blood Glucose Regulation

  • Guideline

    Evaluation Method of Blood Glucose Regulation Effect of Health Food

  • Test system

    Male db/db mice

  • Method

    spontaneously hyperglycemia db/db mice

  • Item

    Fasting and postprandial blood glucose, glucose tolerance test, fasting and postprandial plasma insulin, urine glucose, etc

Gastrointestinal Function Improvement

  • Guideline

    Evaluation Method of Gastrointestinal Function Improvement Effect of Health Food

  • Test system

    SD or Wistar rats

  • Method

    To evaluate whether the test article has one of the following four GI functions through different animal models:

    1.   Improve digestion and absorption

    2.   Improve intestinal microbiota

    3.   Improve gastrointestinal motility

    4.   Contribute to the protection of gastric mucosa

  • Item

    1.   Improve digestion and absorption: body weight, digestibility, enzyme activity

    2.   Improve intestinal microbiota: Bifidobacterium, Clostridium perfringens

    3.   Improve gastrointestinal motility: gastrointestinal motility (activated carbon), gastric mucosal protection, observation of the dry weight, grain number, moisture, and shape of feces

    4.   Contribute to the protection of gastric mucosa:

         (1)   in vitro: survival rate of rat gastric mucosal cells

         (2)   in vivo: determination of gastric acid secretion in rats (Shay’s ulcer method)

Bone Health Protection

  • Guideline

    Evaluation Method of Bone Health Protection Effect of Health Food

  • Test system

    SD or Wistar rats

  • Method

    1.   Growing animal model

    2.   Ovariectomized (OVX) animal model

  • Item

    Body weight, body length, femoral length or femoral plus tibia length, and at least 2 of the following 5 indexes: bone density, determination of trabecular bone, assessment of trabecular mineral apposition rate (MAR), biomechanical analysis, and metabolic biochemical indexes of osteoblast (OB) and osteoclast (OC).