OECD402

SD rats

Evaluating the lethal dosage and LD50 of the chemicals through dermal route to intake into the body

8 weeks

OECD 403

Wistar rats

Evaluating the lethal dosage and LD50 of the chemicals through inhalation route to intake into the body and observing the effects on lung and/or organs

4 months

OECD 407

SD rats

The chemicals was fed orally for 28 day through three different (low, medium and high) dosage. To evaluate the change in the organs and toxicity after repeated feeding.

clinical symptoms, incidence, mortality, fundoscopy, body weight, feed consumption, feed utilization, hematology, serum biochemistry and electrolytes, urology, organ weight, macroscopic and pathological observations, etc. Finally, the results will present as the no observed adverse effect level, NOAEL.

7 to 10 months (pre-test was contained)

OECD 408

SD rats

The chemicals was fed orally for 90 day to evaluate the long-term chronic toxicity. A longer feed period will better to understand the damage on specific tissues and organs. The three different (low, medium and high) dosage were used. To evaluate the change in the organs and toxicity after repeated feeding.

clinical symptoms, incidence, mortality, fundoscopy, body weight, feed consumption, feed utilization, hematology, serum biochemistry and electrolytes, urology, organ weight, macroscopic and pathological observations, etc. Finally, the results will present as the no observed adverse effect level, NOAEL.

12 to 14 months (pre-test was contained)

OECD 414

SD rats

To realize whether long-term chemical use during pregnancy affects maternal, embryonic and offspring development during pregnancy.

12 to 14 months (pre-test was contained)

OECD 202

Daphnia magna

Through observing the lethal rate, LD50, and no observable effect concentration (NOEC) to evaluate the hazard assessment on chemicals affected on Daphnia. sp. in aquatic environment.

3 to 6 months (pre-test was contained)

OECD 201

Through observing the lethal rate, LD50, and no observable effect concentration (NOEC) to evaluate the hazard assessment on chemicals affected on freshwater algae in aquatic environment.

3 to 5 months (pre-test was contained)

OECD 203

zebra fish

Fish are the highest consumers in vertebrates in aquatic environment. We use chemicals to co-cultivate with fish to evaluate the harm, obtain the half-effect concentration (EC50) or no observable effect concentration (NOEC) through mortality.

3 to 6 months (pre-test was contained)

OECD 301F

Microbiome

Incubating the microbiome with chemicals to evaluate the bio-degradation effect and the inhibition effect on microbiome growth.

4 to 6 months