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28 day repeated dosage by oral

  • Guidelines

    OECD 407

  • Test system

    SD rats

  • Test Aims

    The chemicals was fed orally for 28 day through three different (low, medium and high) dosage. To evaluate the change in the organs and toxicity after repeated feeding.

  • Test items included

    clinical symptoms, incidence, mortality, fundoscopy, body weight, feed consumption, feed utilization, hematology, serum biochemistry and electrolytes, urology, organ weight, macroscopic and pathological observations, etc. Finally, the results will present as the no observed adverse effect level, NOAEL.

  • Lead time

    7 to 10 months (pre-test was contained)