90 day repeated dosage by oral

OECD 408

SD rats

The chemicals was fed orally for 90 day to evaluate the long-term chronic toxicity. A longer feed period will better to understand the damage on specific tissues and organs. The three different (low, medium and high) dosage were used. To evaluate the change in the organs and toxicity after repeated feeding.

clinical symptoms, incidence, mortality, fundoscopy, body weight, feed consumption, feed utilization, hematology, serum biochemistry and electrolytes, urology, organ weight, macroscopic and pathological observations, etc. Finally, the results will present as the no observed adverse effect level, NOAEL.

12 to 14 months (pre-test was contained)