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Single dose toxicity

  • Guideline

    OECD423-Acute Oral toxicity

    TFDA 藥品非臨床試驗安全性規範

  • Test system

    1) Rodents: a study of 6 months duration;

    2) Non-rodents: a study of nine months duration.

  • Test Aims

    To test the acute toxic effects of substances in mammals after single dosing (including multiple dosing completed within 24 hours).

    It can used to define a maximum tolerated dose, and the dose setting for Phase 1 clinical trials.