- Guideline
OECD 414、416
TFDA 藥品非臨床試驗安全性規範
- Test system
The preferred rodent species is the rat and the preferred non-rodent species is the rabbit. Justification should be provided if another species is used.
- Test Aims
The test of reproduction to provide general information concerning the effects of a test substance on male and female reproductive performance in different period.
Toxicity tests
Reproductive and Developmental Toxicity Studies
Skin Irritation Study in White Rabbits
- Guideline
OECD 404: Acute Dermal Irritation/Corrosion
- Test system
Rabbits
- Test Aims
Corrosion/irritation likely to arise from exposure to liquid or solid test substance by dermal application.
Skin Sensitization Study in Guinea Pigs (Maximization Test)
- Guideline
OECD406 Skin Sensitisation
TFDA 藥品非臨床試驗安全性規範
- Test system
Guinea pig
- Test Aims
Confirm whether the substance will cause exert skin sensitization in guinea pigs.